The goal of this presentation is to discuss the origin, evolution, and control strategies for H5N1 influenza viruses. The emergence of the virus over the last 10 years will be discussed, as will studies designed to evaluate the preclinical effectiveness of various control strategies, such as vaccination. The speaker for this is Richard J. Webby, Ph.D., an assistant member in the Division of Virology, Department of Infectious Diseases, at St. Jude Children’s Research Hospital in Memphis, Tennessee.